Journal of Pain & Relief
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Lucas Andrade Silva
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Sleep Deficiency and Opioid Use Disorder
Sleep deficiency and Opioid Use Disorder (OUD) are intricately linked, forming a bi-directional relationship that exacerbates the severity of both conditions. Opioids significantly disrupt sleep architecture, reducing slow-wave sleep and REM sleep while increasing sleep fragmentation. Conversely, chronic sleep deprivation enhances pain sensitivity,... Read More»
: J Pain Relief 2025, 14:702
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