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Mark A. Behlke

Integrated DNA Technologies, Inc., 1710 Commercial Park, Coralville, IA 52241, USA

Biography

Dr. Mark Behlke has served as Vice President of Molecular Genetics and Biophysics at Integrated DNA Technologies (IDT) since April 1996, having joined IDT in 1995 as Director of Research. Previously, he was a Physician Postdoctoral Fellow of the Howard Hughes Medical Institute at the Whitehead Institute for Biomedical Research, where he studied human sex determination in the laboratory of Dr. David Page. He was a Resident Physician in Internal Medicine and Fellow in Endocrinology at Brigham and Women's Hospital, Boston.

Publications

Chemical Modification of CRISPR gRNAs Eliminate type I Interferon Responses in Human Peripheral Blood Mononuclear Cells

Objectives: CRISPR/Cas9 is currently the primary tool used for genome editing in mammalian cells. To cleave and alter genomic DNA, both the Cas9 nuclease and a guide RNA (gRNA) must be present in the nucleus. One preferred method of introducing these reagents is direct transfection of a recombinant Cas9 protein complexed with a synthetic gRNA as a ... Read More»

Mollie S. Schubert, Edward Cedrone, Barry Neun, Mark A. Behlke and Marina A. Dobrovolskaia

Case Report: J Cytokine Biol, 3: 121

DOI:

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article