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Ruth Boetzel

Pfizer, Ramsgate Rd, Sandwich, Kent CT13 9ND, UK.

Biography

Ruth Boetzel Pfizer, Ramsgate Rd, Sandwich, Kent CT13 9ND, UK. Published article on The Structural and Energetic Basis for High Selectivity in a High-Affinity Protein-Protein Interaction,Self-recognition by an intrinsically disordered protein.Extensive experience in NMR spectroscopy of small molecules and proteins Structure elucidation of small molecules by NMR and MS Computer-assisted structure elucidation.

Publications

Conformational Dynamics in the Endonuclease Domain of Colicin E

The endonuclease domain of colicin E9 binds Zn2+ in a multi-step process with a substantial increase in stability that has been suggested to result partly from changes in the dynamic properties of the protein as detected by tryptophan fluorescence. We have used NMR and molecular dynamics to investigate the effect of zinc binding on the structure an... Read More»

Nigel J Clayden, Geoffrey R Moore, Emily S Collins and Ruth Boetzel

Research Article: Biopolymers Res 2017, 1: 103

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article