Journal of Pain & Relief
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Tomohiko Aoe
Biography
Tomohiko Aoe is currently working in the Department of Anesthesiology,Tokyo Women's Medical University,Yachiyo Medical Center, Chiba, Japan. Research intrests are Protein quality control, Pain Disorders, ER Stress, Aging, Neurodegenerative Diseases, Chaperones.Publications
Development of Opioid Tolerance and Endoplasmic Reticulum Stress
Opioids are potent analgesics, widely used to control acute and chronic pain. While repeated administration of opioids, particularly morphine, induces tolerance that reduces the effectiveness of the analgesic, the precise molecular mechanism for the development of tolerance remains uncertain. Opioids bind to the μ opioid receptor (MOR) to activa... Read More»
Mini Review: J Pain Relief 2015, 4:174
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