Research Article
Clinicopathological Significance of Fatty Acid Synthase Expression in Carcinoma of the Ampulla of Vater
Hiroshi Maekawa*, Tomoaki Ito, Tomoyuki Kushida, Hajime Orita, Mutsumi Sakurada and Koichi Sato
Department of Surgery, Juntendo university school of medicine Shizuoka hospital, 1129, Nagaoka, Izu-no-kuni, Shizuoka, Japan
- Corresponding Author:
- Hiroshi Maekawa
Department of Surgery
Juntendo university school of medicine Shizuoka hospital
1129, Nagaoka, Izu-no-kuni, Shizuoka, Japan
Tel: 81 559483111
Fax: 81 559460514
E-mail: hmaekawa0201@gmail.com
Received Date: January 2, 2015; Accepted Date: January 19, 2015; Published Date: January 30, 2015
Citation: Maekawa H, Ito T, Kushida T, Hajime Orita H, Sakurada M, et al. (2015) Clinicopathological Significance of Fatty Acid Synthase Expression in Carcinoma of the Ampulla of Vater. J Gastrointest Dig Syst 5:251. doi:10.4172/2161-069X.1000251
Copyright: © 2015 Maekawa H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Objective: Increased fatty acid synthase (FAS) expression is detected in various cancers. It has been demonstrated that the intensity of FAS expression in cancer correlates with clinical outcome. Here, we investigated whether FAS expression in carcinoma of the ampulla of Vater has any relationship to clinical or pathological features.
Methods: We studied 32 patients surgically treated for carcinoma of the ampulla of Vater in our hospital. We compared FAS immunohistochemical staining with other pathological features, including Ki-67, p53, and MUC1, and 2 staining, and with clinical findings.
Results: Of these 32 cases, 16 were considered FAS-positive under our criteria. Pathologically, FAS positivity was correlated to Ki-67 positivity (p: 0.0045), but there was no significant relationship between FAS expression and p53 staining(p: 0.6715). FAS-positive cases showed a higher rate of lymph node metastases (p: 0.0373). However, FAS expression was not related to tumor size, differentiation of adenocarcinoma, duodenal invasion, pancreatic invasion and MUC1 or MUC2 positivity. Clinically, the disease survival rate and the overall survival rate of FAS-positive cases was lower than that of FAS-negative ones (p: 0.0365, 0.0007).
Conclusion: Histological FAS expression is related to aggressiveness of cancer of the ampulla of Vater and FAS expression can be considered to be a prognostic marker in cancer of the ampulla of Vater.
