Identification and Treatment of Juvenile Acute Myeloid Leukaemia Stem Cell Splicing Dysregulation
Received Date: May 01, 2023 / Published Date: May 29, 2023
Abstract
Acute myeloid leukaemia in children (pAML) is characterised by frequent relapses and a dearth of somatic DNA alterations. Splicing dysregulation has not been thoroughly researched in pAML, despite seminal findings showing that splicing factor mutations and mis-splicing fuel therapy-resistant leukaemia stem cell (LSC) production in adults. Here, we discuss transcriptome-wide analyses of FACS-purified hematopoietic stem and progenitor cells followed by differential splicing analyses, dual-fluorescence lentiviral splicing reporter assays, single-cell proteogenomics analyses, and the potential of the selective splicing modulator Rebecsinib in pAML.
Citation: Campbell J (2023) Identification and Treatment of Juvenile Acute MyeloidLeukaemia Stem Cell Splicing Dysregulation. Arch Sci 7: 153. Doi: 10.4172/science.1000153
Copyright: © 2023 Campbell J. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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