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Abstract

The structural architecture of copolymers significantly influences cellular interactions, impacting adhesion, proliferation, and differentiation. This study explores the relationship between copolymer design and cellular morphological responses, focusing on variations in polymer composition, molecular weight, and topological arrangement. Using biophysical techniques such as atomic force microscopy (AFM), fluorescence microscopy, and rheological measurements, we investigate how different copolymer architectures modulate cell shape, cytoskeletal organization, and mechanotransduction pathways. Our findings indicate that block copolymers exhibit enhanced cell adhesion and spreading compared to random copolymers, highlighting the role of nanoscale surface properties in guiding cellular responses. The study provides insights into the development of biomaterial scaffolds for tissue engineering applications.