Patient-Derived Xenograft Models for Cancer Stem Cell Research
Received Date: Jan 01, 2025 / Published Date: Jan 31, 2025
Abstract
Patient-derived xenograft (PDX) models have emerged as a powerful tool in cancer research, providing a clinically relevant platform for studying cancer stem cells (CSCs). These models retain the histological and genetic characteristics of the original tumors, allowing researchers to investigate tumor heterogeneity, treatment resistance, and metastasis. PDX models enable the identification of CSC-specific markers and pathways, facilitating the development of targeted therapies. Furthermore, they serve as an essential preclinical model for evaluating novel therapeutics and predicting patient responses. This review discusses the significance of PDX models in CSC research, their advantages and limitations, and their potential in advancing precision oncology.
Citation: Nag H (2025) Patient-Derived Xenograft Models for Cancer Stem Cell Research Adv Cancer Prev 9: 266. Doi: 10.4172/2472-0429.1000266
Copyright: © 2025 Nag H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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