Role of Fibroblast Growth Factor (FGF) in Suppressing Tumor in Patients with Colorectal Cancer
Received Date: Nov 01, 2022 / Accepted Date: Nov 28, 2022 / Published Date: Nov 29, 2022
Abstract
In colorectal cancer, fibroblast growth factor 14 (FGF14) was selectively methylated (CRC). In this work, we sought to elucidate the biological action, molecular mechanism, and epigenetic control of FGF14 in CRC. By using PCR and Western blot, the expression of FGF14 in CRC cell lines, normal human colon epithelial cell lines, CRC tissues, and matched neighbouring normal tissues was found. FGF14 blocked the PI3K/AKT/mTOR pathway and caused mitochondrial death. In conclusion, FGF14 is a new tumour suppressor that activates the PI3K/AKT/mTOR pathway to mediate cell death and restrict cell growth.
Citation: Javice C (2022) Role of Fibroblast Growth Factor (FGF) in SuppressingTumor in Patients with Colorectal Cancer. World J Pharmacol Toxicol 5: 169. Doi: 10.4172/wjpt.1000169
Copyright: © 2022 Javice C. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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