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Abstract

Isotope Ratio Mass Spectrometry (IRMS) is a powerful analytical technique used for determining the ratios of isotopes in a sample, providing valuable insights into various fields such as environmental science, archaeology, geochemistry, and forensic analysis. The technique’s sensitivity and precision are critical for accurate results, and over the years, several techniques have been developed to enhance these key parameters. This article explores the advancements and methods for improving the sensitivity and precision of IRMS, including innovations in instrumentation, sample preparation, calibration methods, and data analysis techniques. By investigating the latest developments, such as improved ionization techniques, sample purification protocols, and technological upgrades in mass spectrometers, we examine how these approaches contribute to the overall performance of IRMS. Additionally, the challenges associated with achieving higher sensitivity and precision are discussed, along with the potential impact on applications such as climate studies, forensics, and dating methods. Ultimately, this article demonstrates how the continued refinement of IRMS techniques promises to elevate the accuracy of isotope ratio measurements and expand the range of possible applications.