The Pancreatic INS-1E Beta Cells Activation of the TRPV4 Channel Increases the Release of Insulin in Response to Glucose Through Calcium- Dependent Processes
Received Date: Apr 10, 2023 / Accepted Date: May 03, 2023 / Published Date: May 08, 2023
Abstract
Insulin secretion by pancreatic beta cells is a vital process for glucose regulation in the human body. The activation of the Transient Receptor Potential Vanilloid 4 (TRPV4) channel in these cells has recently been recognized as a significant contributor to insulin release. This study investigates the impact of TRPV4 channel activation on insulin secretion in response to glucose, with a particular focus on the involvement of calcium-dependent processes. Glucose-stimulated insulin secretion involves a cascade of events in pancreatic beta cells. Elevated blood glucose levels lead to glucose entry into beta cells and subsequent ATP production. ATP-sensitive potassium channels close as a result of increased ATP levels, leading to membrane depolarization. This depolarization triggers the opening of voltage-gated calcium channels, resulting in calcium influx into the cells.
Citation: Burger H (2023) The Pancreatic INS-1E Beta Cells’ Activation of the TRPV4 Channel Increases the Release of Insulin in Response to Glucose Through Calcium-Dependent Processes. J Clin Diabetes 7: 176.
Copyright: © 2023 Burger H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
Recommended Journals
51ºÚÁϳԹÏÍø Journals
Article Usage
- Total views: 942
- [From(publication date): 0-2023 - Jun 18, 2025]
- Breakdown by view type
- HTML page views: 697
- PDF downloads: 245
