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Abstract

Fibrous dysplasia (FD) is a rare, benign skeletal disorder characterized by the replacement of normal bone and marrow with fibro-osseous tissue, leading to structural weakness, deformity, pain, and functional impairment. Though it can present in monostotic or polyostotic forms, its clinical variability and unpredictable progression pose significant challenges in diagnosis and management. This article explores the pathophysiology, clinical manifestations, diagnostic strategies, and current treatment modalities for FD, emphasizing the complexities involved in managing this enigmatic condition. Insights from recent advances in molecular genetics and targeted therapies are also discussed, shedding light on potential future directions in care. Through a comprehensive review of existing literature and clinical perspectives, this article underscores the importance of a multidisciplinary approach in optimizing outcomes for patients with fibrous dysplasia.