ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
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Genetics and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy
5th International Conference on Alzheimer’s Disease & Dementia
Nadia El Kadmiri
Hassan Ii University of Casablanca, Morocco
Posters & Accepted Abstracts: J Alzheimers Dis Parkinsonism
DOI:
Abstract
Neuroproteomics studies conducted in recent years have highlighted the potential involvement of the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), in Alzheimer Disease (AD) associated proteins, including the �²-amyloid, �²-amyloid precursor. In our previous study we elucidated the critical role of GAPDH and its interaction with �²-amyloid in the blood of Moroccan patients with familial AD (FAD) carrying presenilin mutations. The aim of this current study was to assess the mechanism responsible of decreased expression of GAPDH protein in the blood of Moroccan FAD cases. Our result revealed a non-significant difference of mRNA expression level of GAPDH from FAD cases carrying mutations as compared to healthy controls and FAD case confirmed at autopsy (P> 0.05). Our finding is consistent with several studies by showing the direct involvement of GAPDH in amyloid aggregation; the GAPDH in AD can undergo many different oxidative post-translational modifications, which affects its chemical structure and biological activity. These Data open prospects to clarify more these mechanisms in blood of AD cases by aiming to use GAPDH as a biomarker for diagnostics and monitoring AD modification.Biography
Email: elkadmiri1979@gmail.com
